
PHARMAQUEST
(ii) Selecting a significance level: The hypotheses are tested on a pre-
determined level of significance and as such the same should be specified.
Generally, in practice, either 5% level or 1% level is adopted for the purpose.
The factors that affect the level of significance are: (a) the magnitude of the
difference between sample means; (b) the size of the samples; (c) the
variability of measurements within samples; and (d) whether the hypothesis is
directional or non-directional (A directional hypothesis is one which predicts
the direction of the difference between, say, means). In brief, the level of
significance must be adequate in the context of the purpose and nature of
enquiry.
(iii) Deciding the distribution to use: After deciding the level of significance,
the next step in hypothesis testing is to determine the appropriate sampling
distribution. The choice generally remains between normal distribution and
the t-distribution. The rules for selecting the correct distribution are similar to
those which we have stated earlier in the context of estimation.
(iv) Selecting a random sample and computing an appropriate value: Another
step is to select a random sample(s) and compute an appropriate value from
the sample data concerning the test statistic utilizing the relevant distribution.
In other words, draw a sample to furnish empirical data.
(v) Calculation of the probability: One has then to calculate the probability
that the sample result would diverge as widely as it has from expectations, if
the null hypothesis were in fact true.
(vi) Comparing the probability: Yet another step consists in comparing the
probability thus calculated with the specified value for α, the significance level.
If the calculated probability is equal to or smaller than α value in case of one-
tailed test (and α /2 in case of two-tailed test), then reject the null hypothesis
(i.e., accept the alternative hypothesis), but if the calculated probability is
greater, then accept the null hypothesis. In case we reject H
O
, we run a risk of
(at most the level of significance) committing an error of Type I, but if we
accept H
O
, then we run some risk (the size of which cannot be specified as long
as the H0 happens to be vague rather than specific) of committing an error of
Type II.